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研究表明,给小鼠腹腔注射HgCl_20.5和1.0mg/kg后,其诱发的微核率显著地高于蒸馏水对照组。而给小鼠腹腔注射VC50mg/kg以上,可降低HgCl_2的致微核作用,注射剂量达100和200mg/kg时,其作用更明显(P<0.001)。另外,不论是在HgCl_2染毒前4h或染毒后2h内给子VC,均可明显地降低HgCl_2的致微核作用,尤其是在HgCl_2染毒前30～60min内和染毒后30min时给VC、则其抗致微核作用愈益明显。如给小鼠饮用含VC2.5g/L的水一个月后,也可显著地降低HgCl_2的致微核作用。
Studies have shown that mice injected with HgCl_20.5 and 1.0mg / kg, the induced micronucleus rate was significantly higher than the distilled water control group. However, intraperitoneal injection of VC50mg / kg or more in mice resulted in a decrease of micronuclei induced by HgCl_2. The effect of HgCl_2 was even more pronounced at injection doses of 100 and 200 mg / kg (P <0.001). In addition, the micronuclei of HgCl_2 could be obviously reduced both in 4h before HgCl_2 exposure and 2h after exposure, especially in 30 ~ 60min before HgCl_2 and 30min after exposure VC, the anti-micronucleus effect is more obvious. One month after drinking VC2.5g / L water for mice, the micronuclei of HgCl2 can also be significantly reduced.