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目的观察氟哌噻吨美利曲辛片(黛力新)联合复方利多卡因乳膏治疗带状疱疹后遗神经痛(PHN)并发抑郁的临床疗效和安全性。方法将入选的67例带状疱疹后遗神经痛并发抑郁患者按照就诊顺序随机分为两组,治疗组(34例)予黛力新10.5mg口服(1次/d)和复方利多卡因乳膏外搽皮损(2次/d)。对照组(33例)仅予复方利多卡因乳膏外搽皮损(2次/d)。两组患者的疗程均为4周,分别于治疗前及治疗第7,14和28天用视觉模拟评分法(VAS)评定PHN患者疼痛改善情况,用汉密尔顿抑郁评分(HAMD)评价其抑郁状态改善情况。结果治疗前两组患者的VAS评分:治疗组为7.15±0.99,对照组为7.00±1.06;在治疗7,14和28d,:治疗组分别为4.85±0.86,3.18±0.72,2.21±0.59,对照组分别为5.55±0.75,4.06±0.90,3.15±0.71,两组患者的VAS评分均较治疗前明显下降;而且治疗组的VAS评分和HAMD均明显低于对照组,以上差异均有统计学意义(P均<0.01)。治疗组3例出现失眠,对照组未见明显不良反应。结论黛力新联合复方利多卡因乳膏治疗PHN并发抑郁患者时能明显改善抑郁状态和疼痛症状,安全有效,无严重不良反应。
Objective To observe the clinical efficacy and safety of flupenthixol and melitracen tablets combined with lidocaine cream in the treatment of post-herpetic neuralgia (PHN) complicated with depression. Methods A total of 67 selected patients with postherpetic neuralgia and depression were randomly divided into two groups according to the order of treatment. The treatment group (34 patients) was given oral administration of dextrolidate 10.5 mg once daily and compound lidocaine Cream ointment lesions (2 times / d). The control group (33 cases) only to compound lidocaine cream Waicha lesions (2 times / d). The course of treatment was 4 weeks in both groups. The improvement of pain in PHN patients was assessed by visual analogue scale (VAS) before treatment and on the 7th, 14th and 28th day of treatment, respectively. The Hamilton Depression Rating (HAMD) Happening. Results Before treatment, the VAS score of the two groups was 7.15 ± 0.99 in the treatment group and 7.00 ± 1.06 in the control group. On the 7th, 14th and 28th days after treatment, the VAS scores of the two groups were 4.85 ± 0.86, 3.18 ± 0.72 and 2.21 ± 0.59 respectively, Group were 5.55 ± 0.75,4.06 ± 0.90,3.15 ± 0.71, VAS scores of both groups were significantly lower than before treatment; and the treatment group VAS score and HAMD were significantly lower than the control group, the above differences were statistically significant (P <0.01). Three cases of treatment group insomnia, no obvious adverse reactions in the control group. Conclusion Deanxit combined with compound lidocaine cream can significantly improve depression and pain symptoms in patients with PHN complicated with depression, safe and effective, without serious adverse reactions.