论文部分内容阅读
目的探讨简化调强放疗联合腔内治疗及同步化疗治疗ⅡB~ⅣA期宫颈癌效果及毒副反应。方法 175例ⅡB~ⅣA期宫颈癌患者,根据治疗方式不同分为研究组(90例)与对照组(85例)。研究组实施简化调强放疗联合腔内治疗及同步化疗治疗,对照组实施常规基础放化疗治疗。比较两组患者的放化疗后毒副反应情况及1、2、3年生存率及局部复发率情况。结果研究组患者ⅡB期~ⅢA期、ⅢB期~ⅣA期的放化疗后毒副反应发生率分别为3.33%、4.44%,均优于对照组的20.00%、23.53%(P<0.05);研究组1、2、3年生存率、局部复发率均优于对照组(P<0.05)。结论采用简化调强放疗联合腔内治疗及同步化疗治疗可有效的改善预后,提高患者的生存能力。
Objective To investigate the efficacy and side effects of simplified intensity modulated radiotherapy combined with endovascular therapy and concurrent chemotherapy for stage ⅡB-ⅣA cervical cancer. Methods A total of 175 patients with stage ⅡB-ⅣA cervical cancer were divided into study group (n = 90) and control group (n = 85) according to different treatment methods. The study group to implement simplified IMRT combined with endovascular treatment and concurrent chemotherapy, the control group to implement conventional radiotherapy and chemotherapy. The side effects of radiotherapy and chemotherapy after radiotherapy and chemotherapy and the 1, 2, 3 year survival rate and local recurrence rate were compared between the two groups. Results The incidences of postoperative radiotherapy and chemotherapy were 3.33% and 4.44% in stage ⅡB-ⅢA and ⅢB-ⅣA, respectively, which were all better than those in control group (20.00% and 23.53%, P <0.05) The 1-year, 2-year, 3-year survival rate and local recurrence rate were better than those of the control group (P <0.05). Conclusions The simplified IMRT combined with endovascular treatment and concurrent chemotherapy can effectively improve the prognosis and improve the patients’ viability.