肾功能损害病人的药动学变化和剂量调整肾衰时,尿素在胃尿素酶的作用下转化成氨,由于碱性药物使病人胃内pH升高,从而影响某些药物的吸收。伍用抗酸剂或磷酸盐药物时,可直接与喹诺酮类及磺胺类等口服抗生素产生作用使其生物利用度降低。药物在血中与血浆蛋白包括白蛋白和酸性球蛋白(AAG)的结合率对分布容积(Vd)、游离药 Renal dysfunction in patients with pharmacokinetic changes and dose adjustment Renal failure, the role of urea in the urease under the action of ammonia into ammonia, due to alkaline drugs to increase the pH of the patient’s stomach, thus affecting the absorption of certain drugs. Wu antacids or phosphate drugs, can be directly with the quinolones and sulfa oral antibiotics and other effects to reduce its bioavailability. The binding rate of the drug in the blood to plasma proteins, including albumin and acid globulin (AAG), to the volume of distribution (Vd), free drug