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[目的]探讨纤溶标志物纤溶酶原激活物抑制因子-1(PAI-1)、组织性纤溶酶原激活物(t-PA)、纤维蛋白裂解产物(FDP)、D-二聚体在代谢综合征(MS)发生发展中的作用。[方法]按照国际糖尿病联盟(IDF)2005年亚洲诊断标准,采用1︰1配对病例对照的方法,随机选择136对MS病例与对照。应用Spearman等级相关分析此4种纤溶标志物与MS各组分的关系,条件Logistic回归分析PAI-1、t-PA、FDP、D-二聚体与MS的关系。[结果]4种纤溶标志物与MS组分之间存在不同程度的相关。Logistic回归结果显示除t-PA与MS之间为负相关外,PAI-1、FDP、D-二聚体与MS存在正相关;调整MS其他危险因素,特别是炎症因子hs-CRP与瘦素后,t-PA仍是MS的保护因素,但其与MS的OR值降低;而FDP、D-二聚体在调整后与MS的关联性明显增大。[结论]PAI-1、t-PA、FDP、D-二聚体有可能在MS的发生发展起到重要作用,其中t-PA、FDP、D-二聚体可能是MS的独立影响因素。
[Objective] To investigate the effect of fibrinolytic markers plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (t-PA), fibrin cleavage product (FDP) Body in the development of metabolic syndrome (MS) role. [Methods] According to IDF Asian Diagnostic Criteria in 2005, 136 pairs of MS cases and controls were randomly selected using 1: 1 matched case-control method. Spearman rank correlation analysis of the four fibrinolytic markers and MS components, conditional Logistic regression analysis of PAI-1, t-PA, FDP, D-dimer and MS relationship. [Result] The four fibrinolytic markers correlated with MS components to some extent. Logistic regression analysis showed that there was a positive correlation between PAI-1, FDP and D-dimer and MS except for the negative correlation between t-PA and MS. The other risk factors of MS, especially the relationship between hs-CRP and leptin However, t-PA remained a protective factor of MS, but its OR value with MS decreased. However, the correlation between FDP and D-dimer and MS significantly increased after adjustment. [Conclusion] It is possible that PAI-1, t-PA, FDP and D-dimer play an important role in the development and progression of MS. T-PA, FDP and D-dimer may be independent factors of MS.