单电子还原电位是测定化合物亲电性的一项数值,通过脉冲辐解方法,在pH=7的缓冲溶液中进行测定(用E_7~1表示)。化合物的单电子还原电位负值的绝对值越小,其亲电性也越大,在绝大部份情况下,化合物的辐射致敏作用与其电子亲和性之间有一定的关系,因此可利用E_7~1值作为初步评价亲电性化合物的辐射致敏作用的指标之一。本文报道某些新的乏氧细胞辐射致敏剂——3—硝基—7—氮杂吲哚类化合物的单电子还原电位值 The single electron reduction potential is a measure of the electrophilicity of a compound and is determined by a pulsed radiolysis method in a pH = 7 buffer solution (indicated by E_7 ~ 1). The smaller the absolute value of the negative single electron reduction potential of the compound, the greater the electrophilicity of the compound. In most of the cases, there is a certain relationship between the sensitization effect of the compound and its electron affinity. Therefore, E_7 ~ 1 value was used as one of the primary indicators to evaluate the radiosensitization of electrophilic compounds. In this paper, we report the single-electron reduction potentials of some new hypoxic cell sensitizers, 3-nitro-7-azaindole compounds