呼吸道炎症是哮喘病理生理改变的核心。吸烟与呼吸道感染关系密切,但对于吸烟与哮喘患者呼吸道炎症及其治疗的影响研究甚少。哮喘的研究多集中于从未吸烟的患者,然而证据表明,吸烟可导致哮喘患者对皮质类固醇发生某种程度的耐药。本文阐述了哮喘与吸烟的关系,特别关注吸烟对于哮喘治疗的影响。令人鼓舞的是,停止吸烟至少可部分恢复戒烟的哮喘患者对皮质类固醇的反应性,也是哮喘患者的首要选择。 Airway inflammation is at the core of the pathophysiological changes in asthma. Smoking and respiratory infections are closely related, but little is known about the effects of smoking and asthma on respiratory inflammation and its treatment. Most studies of asthma have focused on people who never smoked, but evidence suggests that smoking can cause asthma to some degree of resistance to corticosteroids. This article describes the relationship between asthma and smoking, with a special focus on the effects of smoking on asthma treatment. Encouragingly, stopping smoking at least partially reactivates corticosteroids in asthmatics who quit smoking, and is also the number one choice for asthmatics.