本期发表Tsevat 等关于结核菌素阳性的20～80岁成人需否异烟肼预防结核病发生的分析,但其分析结果不能影响对个体或群体采用异烟肼预防的决策。因该文所用资料有些不恰当,而几个假设亦不正确。首先是过低估算结核病病死率(0.68%),可能少于实际病死率的1/10。作者引用胸科医院中确诊病例的死亡率。但住入该院者不能代表美国的全部结核病 This issue of the Tsevat et al. Report on the need for isoniazid prophylaxis in tuberculin-positive adults 20 to 80 years of age to prevent tuberculosis but its results do not influence the decision to adopt isoniazid prophylaxis on individuals or groups. Some of the assumptions used are incorrect due to some inappropriate information. The first is to underestimate the case fatality rate (0.68%), which may be less than 1/10 of the actual case fatality rate. The author cites the death rate of confirmed cases in chest hospital. However, those admitted to the hospital can not represent the entire United States tuberculosis