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目的分析枣庄市孕中期产前筛查的临床资料,探讨孕中期产前筛查的最佳时机提供依据。方法回顾性分析枣庄市2011—2013年孕15~20+6周孕妇的产前检查资料,分析各年度及不同孕周孕妇进行产前筛查的临界风险和高风险率。计数资料比较采用χ2检验,P<0.05为差异有统计学意义。结果不同年份孕妇21-三体、18-三体综合征、神经管畸形的高风险率逐渐升高,但差异均无统计学意义(均P>0.05)。不同孕周孕妇21-三体、18-三体综合征临界风险率比较,差异均有统计学意义(均P<0.05),两两比较发现,与17~18+6周孕妇比较,15~16+6、19~20+6周孕妇的21-三体、18-三体综合征临界风险率均较低,差异均有统计学意义(均P<0.05)。结论加强宣教,大力普及产前筛查,选择产前筛查的最佳时机,对预防和控制出生缺陷,提高人口素质具有重要意义。
Objective To analyze the clinical data of prenatal screening in the second trimester of Zaozhuang and to provide evidences for the best timing of antenatal screening in the second trimester of pregnancy. Methods The prenatal data of pregnant women in Zaozhuang from 15-20 + 6 weeks of pregnancy during 2011-2013 were analyzed retrospectively. The critical risk and high risk rate of prenatal screening in pregnant women in different years and years were analyzed. Counting data using χ2 test, P <0.05 for the difference was statistically significant. Results The risk of 21-trisomy, 18-trisomy syndrome and neural tube defects of pregnant women in different years increased gradually, but the difference was not statistically significant (all P> 0.05). The risk of 21-trisomy and 18-trisomy in pregnant women with different gestational weeks were significantly different (all P <0.05). Comparing the pregnant women with 17-18 + 6 weeks pregnant women, The critical risk rates of 21-trisomy and 18-trisomy in 16 + 6 and 19-20 + 6 weeks pregnant women were all lower than those in the control group (all P <0.05). Conclusion It is of great importance to strengthen propaganda and education, popularize prenatal screening and choose the best time for prenatal screening, which is of great significance in preventing and controlling birth defects and improving population quality.