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类风湿性关节炎中超过50%的患者死于心血管疾病,其心源性猝死的发生率是非类风湿性关节炎患者的2倍,且更易发生恶性室性心律失常。类风湿性关节炎致心律失常的机制可能是全身慢性炎症反应激活后,通过加速缺血性心脏病和充血性心力衰竭的发生发展,影响心脏电生理,从而促使心律失常的发生。因此,通过严格控制类风湿性关节炎疾病活动性以降低炎症负担,可能是减少类风湿性关节炎患者心律失常发生风险最有效的干预措施。
More than 50% of patients with rheumatoid arthritis die of cardiovascular disease and their incidence of sudden cardiac death is twice as frequent as non-rheumatoid arthritis and is more likely to develop malignant ventricular arrhythmias. Rheumatoid arthritis induced arrhythmia mechanism may be systemic chronic inflammatory response is activated, by accelerating the development of ischemic heart disease and congestive heart failure, affecting cardiac electrophysiology, thereby contributing to the arrhythmia. Therefore, by strictly controlling rheumatoid arthritis disease activity to reduce the burden of inflammation may be the most effective intervention to reduce the risk of arrhythmia in patients with rheumatoid arthritis.