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目的 探讨苦参素对慢性肝炎TNF -α、IL -6的影响。方法 87例CHB ,随机分为A、B两组。A组采用苦参素治疗 ;B组甘利欣治疗 ,疗程 3个月。观察肝脏组织及血清中肝功、肿瘤坏死因子 (TNF -α)、IL -6的变化。结果 苦参素可明显改善肝细胞损伤 ,显著降低血清中TNF -α、IL -6的水平 ,与对照组对比差异有显著性 (P <0 0 5 )。结论 苦参素的保肝作用 ,可能与抑制TNF -α、IL -6等介质释放有关。
Objective To investigate the effect of oxymatrine on TNF-α and IL-6 in chronic hepatitis patients. Methods 87 cases of CHB were randomly divided into A and B groups. Group A was treated with oxymatrine; group B was treated with Ganlixin for 3 months. The changes of liver function, tumor necrosis factor (TNF-α) and IL-6 in liver tissue and serum were observed. Results Oxymatrine significantly improved hepatocyte injury and significantly reduced serum TNF-α and IL-6 levels, which was significantly different from the control group (P < 0.05). Conclusion The hepatoprotective effect of oxymatrine may be related to the inhibition of the release of TNF-α and IL-6.