已知Myriocin (+)-thermozymocidin ISP-1为喜热性真菌产生的抗生物质,最近从冬虫夏草菌的代谢产物中也有发现,并具有强的免疫抑制活性。此次作为以糖质为素材的生物活性物质合成研究的一环,进行了myriocin的合成研究。将容易从D-葡萄糖衍生的2-脱氧-D-葡萄糖(1)作为起始物质,经过生成酮体2,对2的羰基的二氯甲基锂的立体选择性的加成反应,以及叠氮基化的多个 It is known that Myriocin (+) - thermozymocidin ISP-1 is an antimicrobial substance produced by a thermophilic fungus and was recently also found in the metabolites of Cordyceps sinensis and has strong immunosuppressive activity. The synthesis of myriocin was studied as part of the synthesis of biologically active substances based on glucocorticoids. A 2-deoxy-D-glucose (1) derived from D-glucose is easily used as a starting material to undergo stereoselective addition reaction with ketone body 2 to dichloromethyl lithium of 2 carbonyl groups, Multiple nitrogens