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电镜观测苯丙酸雌二醇（ＥＢ）和乙酸孕酮（ＨＰＣ）对雌性小鼠下丘脑腹内侧核神经元多聚核糖体的影响。根据雌鼠的动惰周期，对切除卵巢的幼鼠（ＯＶＸ）每５天分别肌肉注射１次８μｇＥＢ、２ｍｇＨＰＣ或８μｇＥＢ加２ｍｇＨＰＣ。疗程２个月。结果显示：（１）神经元胞质中游离型多聚核糖体每μｍ２的含量在ＯＶＸ组与正常组（ＩＮＴ）、ＯＶＸ＋ＥＢ组、ＯＶＸ＋ＨＰＣ组和ＯＶＸ＋ＥＢ、ＨＰＣ组比较均无显著差异（Ｐ＞０．０５）。（２）附着粗面内质网膜表面的结台型多聚核糖体每μｍ含量在ＯＶＸ组分别比ＩＮＴ组、ＯＶＸ＋ＥＢ组、ＯＶＸ＋ＨＰＣ组和ＯＶＸ＋ＥＢ．ＨＰＣ组少２９．８％、２６．２％、３５．２％和３３．７％，均有非常显著差异（Ｐ＜０．００５）。本实验结果证实雌性激素特别是孕酮在小鼠生育早期使下丘脑腹内侧核神经元结合型多聚核糖体含量增多。
Effects of estradiol phenylpropionate and acetic acid progesterone on the multinuclear neurons of hypothalamic venom of hypothalamus in female mice. Ovariectomized pups (OVX) were intramuscularly injected with 8 μg of EB, 2 mg of HPC, or 8 μg of EB plus 2 mg of HPC every 5 days, depending on the passive period of the female rats. Course of 2 months. The results showed that: (1) There was no significant difference in the content of free polysaccharides in the cytoplasm of neurons between the OVX group and the normal group (INT), OVX + EB group, OVX + HPC group and OVX + EB, HPC group .05). (2) Peripheral blood mononuclear cells adhered to the surface of rough endoplasmic reticulum membrane per microgram of content in the OVX group than INT group, OVX + EB group, OVX + HPC group and OVX + EB. HPC group, 29.8% less, 26.2%, 35.2% and 33.7% less, there was a significant difference (P <0.005). The results of this experiment confirmed that estrogen, especially progesterone, increased the content of neuronal-associated polysome ribosomes in the hypothalamic ventrolateral medulla in the early stage of reproductive development in mice.