【答】红霉素由于毒性低微和疗效显著,已成为常用的抗生素之一。有些医生在使用红霉素肠溶片时,常与碳酸氢钠合用,据报道两者不宜合用。由于红霉素的肠溶衣在肠液中溶解的主要因素在于它的解离作用,肠溶衣的材料分子中有弱酸性基团在酸中不解离、不溶解,但在pH较高的肠液中则解离 【Answer】 Erythromycin has become one of the most commonly used antibiotics because of its low toxicity and significant therapeutic effect. Some doctors in the use of erythromycin enteric-coated tablets, often combined with sodium bicarbonate, it was reported that the two should not be combined. Since the main factor of erythromycin enteric coating dissolving in intestinal juice is its dissociation, enteric-coated material molecules have weak acid groups which are not dissociated and insoluble in acid, Intestinal fluid is dissociated