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辅酶Q(CoQ)或泛醌,是由表示氧化还原活性的苯醌骨架和类异戊二烯单位为n组成的同族体的总称。本稿中,氧化型用CoQn表示,含有2个电子的还原型用CoQnH_2表示。天然中存在着n=1～12的同族体,哺乳类以n=9(小鼠、大鼠等)或10(兔、狗、人等)为主。 CoQ的主要生理作用是作为线粒体的电子传递系的成分,在氧化磷酸化生成ATP过程中起重要作用。近来还有一个引人注目的作用是,在机体内具有作为抗氧化物质的机能。与很多起因于活性氧生成的疾病相关连,与α-维生素E(α-Toc)相同,作为切断至过氧化脂质生成连锁反应中的抗氧化物质之一,CoQnH_2起作用的证据正在累积中。
Coenzyme Q (CoQ) or ubiquinone is a generic name of a homologue composed of a benzoquinone skeleton representing a redox activity and an isoprenoid unit of n. In this document, CoQn for oxidized type is represented as CoQnH 2 for reduced type containing two electrons. In nature, n = 1 to 12 congeners exist, and mammals are predominantly n = 9 (mice, rats, etc.) or 10 (rabbits, dogs, humans, etc.). The major physiological role of CoQ, as a component of the mitochondrial electron transport system, plays an important role in the oxidative phosphorylation of ATP. There is also a compelling effect recently that has the function of being an antioxidant substance in the body. Associated with many diseases caused by reactive oxygen species, as is the case with alpha-Toc, evidence of CoQnH2 functioning is one of the antioxidant substances that cut into the lipid peroxidation chain reaction and is accumulating .