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目的探讨广东地区子宫内膜异位症的危险因素,了解该病的流行趋势和特点。方法采用病例对照研究的方法,调查广东地区患者/人士,病例组选取2003年1月至2007年1月经腹腔镜和(或)病理确诊子宫内膜异位症者188例,对照组为健康人群中随机抽样育龄妇女271例。对两组月经和生育情况、既往病史、家族史、生活习惯、劳动情况等方面进行单因素分析,继而采用多因素Logistic回归分析筛选患病相关因素。结果多因素Logistic回归分析提示BMI<20kg/m2(OR=5.823,95%CI为1.834～18.491)、人工流产(OR=5.483,95%CI为1.056～28.472)、自然流产(OR=34.207,95%CI为1.480～790.783)、个人卫生情况较差(OR=14.784,95%CI为3.737～58.488)、怀孕次数2次及以上(OR=0.024,95%CI为0.004～0.161)与本地区子宫内膜异位症有关。结论在广东地区BMI较小、人工流产、自然流产、个人卫生情况差是子宫内膜异位症的危险因素,而怀孕次数多是本病的保护因素。
Objective To explore the risk factors of endometriosis in Guangdong and to understand the epidemiological trend and characteristics of the disease. Methods A case-control study was conducted to investigate the patients / patients in Guangdong. 188 patients with endometriosis confirmed by laparoscopy and / or pathology from January 2003 to January 2007 were selected as the case group and the healthy control group 271 women of childbearing age were randomly sampled. Two groups of menstruation and fertility, past medical history, family history, living habits, labor conditions and other aspects of univariate analysis, followed by multivariate logistic regression analysis of screening for the disease-related factors. Results Multivariate Logistic regression analysis showed that the BMI <20kg / m2 (OR = 5.823,95% CI 1.834 ~ 18.491), abortion (OR = 5.483, 95% CI 1.056-28.472), spontaneous abortion % CI 1.480 ~ 790.783), poor personal hygiene (OR = 14.784,95% CI 3.737-58.488), pregnancy frequency 2 times or more (OR = 0.024,95% CI 0.004-0.161) Endometriosis related. Conclusions In Guangdong, BMI is small, abortion, spontaneous abortion and poor personal hygiene are risk factors of endometriosis. Pregnancy frequency is the most protective factor of this disease.