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为了判断全反式维甲酸(ATRA)在改善难治性复发性急性早幼粒细胞白血病(APL)预后的作用,作者对自1972年1月至1995年11月诊治的108例APL病人中,45例常规化疗无效或首次复发病例进行了回顾性研究,其中,43例在获第1次完全缓解(CR)后复发,2例对常规诱导化疗无效。45例中,7例死于再诱导化疗前;35例接受了一个疗程的再诱导化疗(蒽环类+阿糖胞苷),其中13例自1990年起使
To determine the role of all-trans retinoic acid (ATRA) in improving the prognosis of refractory relapsed acute promyelocytic leukemia (APL), the authors of 108 patients with APL who were diagnosed and treated from January 1972 to November 1995, A retrospective study of 45 cases of conventional chemotherapy failure or first recurrence was performed. Among them, 43 cases had recurrence after the first complete remission (CR), and 2 cases had no effect on conventional induction chemotherapy. Of the 45 patients, 7 died before reinduction chemotherapy; 35 patients received a course of reinduction chemotherapy (anthracycline + cytarabine), of which 13 were initiated since 1990.