单纯疱疹脑炎(HSE)死亡率高,所以早期诊断和及时治疗十分重要。本文报告了一例经脑活检证实的HSE,分析了早期的MRI、CT扫描、EEG和CSF结果的相互关系。认为MRI和EEG的早期有异常,而CT和CSF无改变。强调脑活检有高度的敏感性和特异性。患者男性黑人,64岁,住院前因精神异常、头 HSE mortality is high, so early diagnosis and timely treatment is very important. This article reports a case of HSE confirmed by brain biopsy and analyzes the correlation between early MRI, CT scan, EEG and CSF results. Early MRI and EEG abnormalities were considered, while CT and CSF were unchanged. Emphasis on brain biopsy has a high degree of sensitivity and specificity. Male black, 64 years old, hospitalized due to mental disorders, head