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目的探讨拜阿司匹林和降纤酶治疗频发短暂性脑缺血发作(TIA)的临床疗效。方法 80例TIA均为我院神经内科住院患者,随机分成治疗组和对照组各40例。治疗组男30例,女10例,平均年龄(55±13.6)岁,其中,颈内动脉系统TIA29例,椎基底动脉系统TIA11例;对照组男26例,女14例,平均年龄(56±12.9)岁,其中,颈内动脉系统TIA30例,椎基底动脉系统TIA10例。二组的年龄、性别、发作频率、发作持续时间、病程、并发症及血液流变学指标经统计学处理差异无统计学意义(P>0.05)。治疗组应用口服拜阿司匹灵片(100mg/片)100mg,每晚一次;降纤酶首次10U,以后5U,加入生理盐水250ml静滴,隔日一次,共10d。对照组应用口服阿司匹林片(25mg/片)150mg,每晚一次;川芎嗪注射液120mg加入生理盐水250ml静滴,1次/d,共10d。结果经治疗,治疗组TIA发作终止时间<24h 29例(72.5%);24～72h 8例(20.0%);>72h 3例(7.5%)。对照组分别为20例(50%)、11例(27.5%)、9例(22.5%)。二组72h内总有效率差异有统计学意义(P<0.05)。并且二组治疗前后血液流变性对比有差异有统计学意义(P<0.05)。结论拜阿司匹林联合降纤酶治疗TIA疗效显著。
Objective To investigate the clinical efficacy of aspirin and defibrase in the treatment of frequent transient ischemic attack (TIA). Methods Eighty patients with TIA were hospitalized in neurology department of our hospital and randomly divided into treatment group and control group, 40 cases each. The treatment group, 30 males and 10 females, mean age (55 ± 13.6) years, of which, internal carotid artery TIA29 cases, vertebrobasilar system TIA11 cases; control group, 26 males and 14 females, mean age (56 ± 12.9) years old, among them, 30 cases of TIA in internal carotid artery system and 10 cases of TIA in vertebrobasilar artery system. The two groups of age, gender, frequency of seizures, duration of seizures, duration, complications and hemorheology indicators no statistically significant difference (P> 0.05). The treatment group was treated with oral aspirin tablets (100mg / tablet) 100mg once night; defibrase first 10U, after 5U, added 250ml normal saline infusion, every other day, a total of 10d. The control group was given oral aspirin tablets (25mg / tablet) 150mg once night; ligustrazine injection 120mg saline 250ml intravenous infusion, 1 time / d, a total of 10d. Results After treatment, the termination of TIA in the treatment group was less than 24h in 24 patients (72.5%), 8 (20.0%) in 24-72h and 3 (7.5%) in> 72h. The control group were 20 cases (50%), 11 cases (27.5%) and 9 cases (22.5%). The total effective rate within 72 hours in the two groups was statistically significant (P <0.05). And the two groups before and after treatment of blood rheology compared with the difference was statistically significant (P <0.05). Conclusion Aspirin combined with defibrase in the treatment of TIA significant effect.