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近年来乙胺碘呋酮广泛用于治疗心绞痛和心率失常,但有多种毒副反应。作者就其肺部并发症,结合自己的病例和文献报道的51例,加以综述。一、病原学并发肺部病变的发生率为1.4%～20%;年龄40～81岁;多见于男性;药物剂量200～1,000mg/d。美国报道的病例较欧洲多,前者用药剂量较大,尤其在开始治疗的头15天,采用冲击治疗,剂量大于1.0g。疗程平均为19个月16天(1个月～9年)。累计剂量为12.0～501g。并发肺病组与未并发肺病组平均用药剂量无明显差别。二、症状学 (一)发现方式和临床表现:就诊方式不一。据31例临床资料:活动后气促、乏力、厌食、消瘦20
In recent years, amiodarone is widely used in the treatment of angina pectoris and arrhythmia, but a variety of toxic and side effects. The authors reviewed their pulmonary complications, combined with their own cases and reported in the literature of 51 cases. First, the incidence of pulmonary pathogenesis of pulmonary disease was 1.4% to 20%; aged 40 to 81 years old; more common in men; drug dose 200 ~ 1,000mg / d. The United States reported more cases than in Europe, the former a larger dose, especially in the first 15 days of treatment, the impact of treatment, the dose is greater than 1.0g. The average course of treatment was 19 months and 16 days (1 month to 9 years). The cumulative dose of 12.0 ~ 501g. There was no significant difference in the average dosage between patients with concurrent lung disease and those without concurrent lung disease. Second, symptoms (a) to find the way and clinical manifestations: different treatment methods. According to 31 cases of clinical data: shortness of breath after activities, fatigue, anorexia, weight loss 20