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甲苯胺蓝为一种异染性噻嗪染料,无毒性,易溶于水,对核酸有亲和力,故早已应用于病理学中。近10余年来亦用于口腔癌的诊断。作者采用2％甲苯胺蓝以诊断喉部病变,谓喉正常粘膜、喉部白斑、角化及乳头状瘤不着色,但细胞变异、喉原位癌及浸润性癌易染色。方法:用全身麻醉,气管内插管,并打气阻塞。用悬吊喉镜暴露喉部,吸净喉部粘液,然后涂以2％甲苯胺蓝。待15～20秒钟,用生理盐水冲洗喉部。观察喉部有无染色区,并在着色处进行活组织检查。检查完毕,取出喉镜及气管内插管。
Toluidine Blue is a metachromatic thiazine dye that is nontoxic, soluble in water, and has affinity for nucleic acids. It has long been used in pathology. It has also been used for the diagnosis of oral cancer for more than 10 years. The authors used 2% toluidine blue for diagnosing laryngeal lesions. Normal mucosa, laryngeal leukoplakia, keratoses, and papillomas were not stained, but cell variability, laryngeal carcinoma in situ, and invasive carcinoma were easily stained. Methods: General anesthesia, endotracheal intubation, and inspiratory obstruction. A laryngoscope was used to expose the throat, the throat mucus was aspirated and then coated with 2% toluidine blue. Wait 15 to 20 seconds and flush the throat with normal saline. Observe the presence of a stained area in the throat and perform a biopsy at the stained area. After the examination was completed, the laryngoscope and endotracheal tube were removed.