按随机分组灌胃法测定小鼠敌敌畏(DDVP)和甲基对硫磷(M P)的LD_(50)±L_(95)(斜率)为337±77(6.5291)和105±38(3.7481)m g·kg~(-1),两者对比P<0.001.观察DDVP(ig)的致死时间发现是剂量依赖性(P<0.05).其双曲线型四参数模型Ⅱ的拟合方程为;(?)=41.9206/(InX—4.5681)~(3.2743)+2.8916.DDVP2000 mg·kg~(-1)剂量组的致死时间为4.0±0min(n=6).而MP4500 mg·kg~(-1)剂量组为10.3±5.2 min(n=6)。结果表明DDVP致小鼠死亡作用存在双曲线型时反应量—效关系.且毒性的时间强度高于MP。 The LD_ (50) ± L_ (95) (slope) of mice treated with DDVP and MP were 337 ± 77 (6.5291) and 105 ± 38 (3.7481) mg · Kg -1, the difference between them was P <0.001. The lethal time of DDVP (ig) was observed in a dose-dependent manner (P <0.05). The fitted equation of hyperbolic four-parameter model Ⅱ was: ) = 41.9206 / (InX-4.5681) ~ (3.2743) +2.88916. The lethal time of DDVP2000 mg · kg -1 group was 4.0 ± 0 min (n = 6), while MP4500 mg · kg -1 The dose group was 10.3 ± 5.2 min (n = 6). The results showed that there was a hyperbolic time-response-dose-response relationship in DDVP-induced mice, and the time intensity of toxicity was higher than MP.