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多囊卵巢综合征(PCOS)是一种复杂、多系统的内分泌代谢疾病,病因多元,受多基因遗传和环境因素等共同影响。PCOS女性的肥胖比例明显高于普通女性,故PCOS患者常易出现明显的脂肪功能紊乱和代谢综合征。近年对脂肪组织分泌的重要细胞因子脂联素及脂联素受体的研究发现,脂联素与PCOS中的胰岛素抵抗、远期心血管疾病的发生密切相关;高分子质量脂联素较总脂联素或许更能反映PCOS血清脂联素水平与胰岛素抵抗的关系;脂联素编码基因的多态性使脂联素基因在PCOS中存在易感性。因此,脂联素已成为PCOS的研究热点。
Polycystic ovary syndrome (PCOS) is a complex and multi-system endocrine and metabolic disease with multiple etiologies and multiple genetic and environmental factors. Obesity in PCOS women was significantly higher than the average female, so PCOS patients often prone to significant fat dysfunction and metabolic syndrome. Adipose tissue in recent years, an important cytokine adiponectin and adiponectin receptor study found that adiponectin and PCOS in insulin resistance, long-term cardiovascular disease is closely related to the quality of adiponectin than the total Adiponectin may reflect the relationship between PCOS serum adiponectin and insulin resistance. The polymorphism of adiponectin gene may make adiponectin gene susceptible to PCOS. Therefore, adiponectin has become a research focus of PCOS.