肾细胞癌是泌尿系常见恶性肿瘤之一,其发病率占全身恶性肿瘤的3%左右,其中肾透明细胞癌占80%左右[1]。肾细胞癌的发病机制、发生、发展、转移等生物学行为复杂多变,其中肿瘤新生血管的形成占极为重要地位。环氧化酶-2(cyc looxge-nase-2,COX-2)及内皮抑素基因(Endostatin Gene) Renal cell carcinoma is one of the common malignant neoplasms of the urinary tract, the incidence of which accounts for about 3% of the whole body malignant tumors, of which renal clear cell carcinoma accounts for about 80% [1]. The pathogenesis of renal cell carcinoma, occurrence, development, metastasis and other biological behavior is complex and changeable, in which the formation of tumor neovascularization is extremely important. Cyclooxygenase-2 (COX-2) and Endostatin Gene