目的 探讨钩端螺旋体病(钩体病)流行规律,分析存在问题。方法 用MAT法检测病人、水鸭和蛙血清抗体;同时分离培养病原体。用夹夜法捕鼠,采集鼠肾、猪肾、牛中段尿、蛙肾、水鸭肾和蚂蝗血分离培养病原体。结果 1997～2000年全省共发生钩体病789例,平均发病率为0.44/10万,死亡12人,平均病死率为1.52％。衢州、丽水和台州市的发病数占全省发病总数的93.28％。病例主要分布在7～10月,占95.06％。病人血清抗体阳性率为65.43％,菌群主要为黄疸出血群和七日热群。病人血培养阳性率为1.20％。鼠密度为5.08％,以黑线姬鼠为优势种,占47.34％。鼠带菌率为6.90％,黑线姬鼠带菌率为13.19％。蛙肾阳性率为0.17％。水鸭血清抗体阳性率为50％,菌株主要为秋季群;蛙血抗体阳性率为13.64％,菌株为秋季群。结论 钩体病防制工作不能放松,要加强对该病的监测和防治工作。 Objective To investigate the prevalence of leptospirosis (leptospirosis) and analyze the existing problems. Methods The MAT method was used to detect the serum antibodies of patients, teal and frogs. At the same time, the pathogens were isolated and cultured. Catching the night with the method of catching rats, collecting rat kidney, pig kidney, mid-urine of urchins, frog kidney, water duck kidney and leech blood separation and culture of pathogens. Results From 1997 to 2000, a total of 789 cases of leptospirosis occurred in the province, with an average incidence of 0.44 / 100 000 and 12 deaths with an average mortality rate of 1.52%. The incidence of Quzhou, Lishui and Taizhou accounted for 93.28% of the total incidence in the province. The cases mainly distributed in July to October, accounting for 95.06%. The positive rate of the patient’s serum antibody was 65.43%. The flora mainly consisted of jaundice hemorrhage and seven-day fever group. The positive rate of blood culture in patients was 1.20%. The rat density was 5.08%, and Apodemus agrarius was the dominant species, accounting for 47.34%. The carrying rate of rats was 6.90%, while the carrying rate of Apodemus agrarius was 13.19%. Frog kidney positive rate was 0.17%. Duck serum antibody positive rate was 50%, the main strains of the autumn group; frog blood antibody positive rate was 13.64%, the strain is the autumn group. Conclusion Leptospirosis prevention work can not be relaxed, to strengthen the monitoring and prevention of the disease work.