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目的：探讨微创治疗退变性腰椎滑脱的临床效果。方法选取于2009年6月至2012年12月来我院就诊的退变性腰椎滑脱患者19例，该组患者均采用经Quadrant通道行TILF联合UPASSI 经皮椎弓根螺钉内固定的治疗方法，对其临床资料进行回顾性分析，观察临床效果。结果所有患者均手术成功，术中出血量少、手术时间短，均无神经损伤、硬脊膜破裂、局部血肿等并发症发生，出院后随访12-36个月，行X线拍片检查示滑脱复位良好，内固定位置良好，无断钉及融合器移位、塌陷。结论对于退变性腰椎滑脱患者行微创治疗临床效果良好，大大减轻了患者的痛苦，可在临床推广使用。“,”Objective To explore the clinical effect of minimal y invasive treatment of lumbar degenerative spondylolisthesis. Methods 19 patients with degenerative lumbar spondylolisthesis from 2009 June to 2012 December in our hospital for treatment of patients, the patients were treated by Quadrant channel for TILF combined with UPASSI in the treatment of percutaneous pedicle screw fixation, and the clinical data were analyzed retrospectively, clinical effect. Results al the patients had successful operation, less bleeding, short operation time, no nerve injury, dural rupture, local hematoma and other complications, were fol owed up for 12 to 36 months, for X-ray examination showed good reduction, internal fixation in good position, no broken screw and cage shift, col apse. Conclusion for degenerative lumbar spondylolisthesis patients underwent minimal y invasive treatment of clinical effect is good, can reduce the pain of patients, and can be widely used in clinic.