骨质疏松症是病因复杂多因素的疾病。其原因涉及遗传、内分泌、代谢、营养和物理等方面。掌握骨代谢的关键是骨细胞的动态变化,破骨细胞使骨吸收和成骨细胞使骨生成的平衡决定骨量。骨吸收比骨生成多时,骨量减少导致骨质疏松症,其治疗是用某种方法去抑制破骨细胞,而刺激成骨细胞,以改善两者间平衡,阻止骨量减少或增加骨量。一、骨质疏松症的病理生理骨质疏松症女性远比男性多见。随着年龄的增长,在女性闭经后数年间主要为骨吸收致使骨量急剧减少,引起闭经后骨质疏松症。此后,可产生持续性骨量减少,男女皆可发生,此为老年性骨质疏松症。闭经后,由于雌激素分泌停止,其影响能持续相当长时 Osteoporosis is a complicated and multifactorial disease. The reasons include genetic, endocrine, metabolic, nutritional and physical aspects. Master bone metabolism is the key to the dynamic changes of bone cells, osteoclasts and osteoblasts make the balance of bone formation to determine the amount of bone formation. Osteoporosis occurs when bone resorption is more than bone formation, and its treatment is to treat osteoclasts in some way to stimulate osteoblasts in order to improve the balance between the two, to prevent bone loss or to increase bone mass . First, the pathophysiology of osteoporosis Osteoporosis women more common than men. With age, a few years after amenorrhea in women mainly due to bone resorption resulting in a sharp decrease in bone mass, causing postmenopausal osteoporosis. Since then, can produce persistent osteopenia, both men and women can occur, this is senile osteoporosis. After amenorrhea, due to the cessation of estrogen secretion, the impact can continue for a long time