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1例87岁老年女性患者因高血压自行服用硝苯地平10mg,3次/d。第2天,患者颈、躯干、腹背出现潮红伴瘙痒,四肢肿胀及体温升高。入院查体:T38℃,R98次/min;局部皮肤出现脱屑,占体表面积1/4。实验室检查:WBC17.5×109/L,中性粒细胞数14.8×109/L。诊断为药物性剥脱性皮炎。给予左西替利嗪、葡萄糖酸钙、西米替丁、地塞米松治疗。8d后患者T36.8℃,R20次/min,WBC9.7×109/L,中性粒细胞数8.25×109/L,皮肤潮红、瘙痒减轻,肢体胀肿消退而出院。
One 87-year-old female patient took nifedipine 10 mg 3 times daily for hypertension. On the second day, the patient’s neck, trunk, abdomen with flushing itching, swelling of limbs and body temperature. Admission examination: T38 ℃, R98 times / min; local skin desquamation, accounting for the body surface area 1/4. Laboratory tests: WBC17.5 × 109 / L, the number of neutrophils 14.8 × 109 / L. Diagnosis of drug-exfoliative dermatitis. Give levocetirizine, calcium gluconate, cimetidine, dexamethasone treatment. After 8 days, T36.8 ℃, R20 times / min, WBC9.7 × 109 / L, neutrophil count 8.25 × 109 / L, skin flushing, pruritus, limb swelling and subsidence and discharged.