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目的:观察自拟中药复方丹贞合剂治疗绝经后妇女脂质代谢紊乱的临床疗效以及对相关机制进行分析。方法:将136例脂代谢紊乱患者随机分成两组。治疗组68例采用丹贞合剂加减治疗,对照组68例采用血脂康胶囊治疗。疗程均为8周,观察两组治疗前后总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、促卵泡生成素(FSH)、雌激素(E2)水平的变化。结果:治疗组与对照组均可使血清TC、TG、LDL-C降低(P<0.05),两组比较,差异无统计学意义。治疗组升高E2,并与对照组比较有显著差异(P<0.05);治疗组降低FSH(P<0.05),但组间无明显差异。结论:丹贞合剂补肾祛瘀,平调阴阳,调节绝经后妇女脂质代谢紊乱机制应与促进雌激素升高,改善绝经后妇女内分泌功能有一定关系。
OBJECTIVE: To observe the clinical efficacy of self-made Danzhong Mixture for treating lipid disorders in postmenopausal women and to analyze the related mechanisms. Methods: 136 patients with dyslipidemia were randomly divided into two groups. Sixty-eight patients in the treatment group were treated with Dan-Zhen mixture and 68 in the control group were treated with Xuezhikang Capsule. The course of treatment was 8 weeks. The levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), follicle stimulating hormone (FSH), estrogen (E2) levels. Results: The levels of serum TC, TG and LDL-C in treatment group and control group decreased (P <0.05). There was no significant difference between the two groups. Treatment group increased E2, and compared with the control group were significantly different (P <0.05); treatment group decreased FSH (P <0.05), but no significant difference between the groups. Conclusion: Danzhong Mixture can tonify kidney and remove stasis, regulate yin and yang, and regulate the mechanism of dyslipidemia in postmenopausal women should be related to the promotion of estrogen and the improvement of endocrine function in postmenopausal women.