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C57BL/6N小鼠尾静脉注射B16黑色素瘤细胞1×105后,腹腔注射脂质体白细胞介素Ⅱ(IL-2)0.2,1和5万U·kg-1,连续10d,小鼠肺湿重减少0.2%,11.9%,13.7%;肺转移结节数减少-5.7%,39.6%,48.1%;ConA诱导的脾细胞DNA掺入量增加6.8%,61.9%,95.9%。小鼠环磷酰胺50mg·kg-1,ip3d后,尾静脉注射瘤细胞,实验处理同上,小鼠肺湿重减少1.7%,12.3%,18.1%;肺转移结节数减少9.6%,41.8%,65.0%;脾细胞DNA掺入量增加19.5%,78.5%,115.1%。本文结果表明,IL-2可抑制小鼠B16黑色素瘤肺转移,促进ConA刺激的脾细胞增殖,并与剂量明显相关。对免疫功能受抑小鼠作用更为明显
After injection of B16 melanoma cells in tail vein of C57BL/6N mice (1×10 5 ), liposome interleukin (IL-2) 0.2, 1 and 50,000 U·kg-1 were intraperitoneally injected for 10 consecutive days. Weight loss decreased by 0.2%, 11.9%, and 13.7%. The number of metastatic lung nodules decreased by -5.7%, 39.6%, and 48.1%. ConA-induced splenocyte DNA incorporation increased by 6.8%, 61.9%, and 95.9%. After mice cyclophosphamide 50 mg·kg-1, ip3d, tumor cells were injected into the tail vein. The experimental treatment was the same as above. The lung wet weight of mice was decreased by 1.7%, 12.3%, 18.1%; the number of lung metastatic nodules was reduced by 9.6%, 41.8%. 65.0%; splenocyte DNA incorporation increased by 19.5%, 78.5%, and 115.1%. The results of this study indicate that IL-2 inhibits lung metastasis of mouse B16 melanoma and promotes proliferation of ConA-stimulated splenocytes, and is significantly associated with dose. More pronounced effects on immunocompetent mice