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本文用复方己酸孕酮注射液(EP)给雌性大鼠以及不同品系雌性和雄性小鼠肌内注射,剂量按体重折合成人的5—100倍,每月注射1次或2次,共10—32次。部分实验与钴-60γ线联合应用,全身照射3Gy,1次或2次,观察其致癌和有害的非致癌效应。实验结果表明,EP具有明显的致癌作用;与γ线联合应用明显加重γ线的致癌作用。本文对EP的致癌机制也进行了讨论。
In this article, compound prohexanoic acid progesterone injection (EP) was given intramuscularly to female rats and different strains of female and male mice. The dose was 5 to 100 times as much as human body weight and was injected once or twice per month for a total of 10 - 32 times. Some of the experiments were combined with cobalt-60 gamma rays, and 3Gy was irradiated whole body once or twice to observe its carcinogenic and harmful non-carcinogenic effects. The experimental results show that EP has a significant carcinogenic effect; combined with the application of γ-ray significantly aggravate the carcinogenesis of γ-ray. This article also discusses the carcinogenic mechanism of EP.