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亚硒酸钠(Na_2SeO_3)预防克山病急发和治疗大骨节病均有显著效果,现已推广应用,但其临床安全有效剂量,用药间隔,有无蓄积毒性等均未解决。因此,本室研究了亚硒酸钠在正常人体内的药代动力学。
Sodium selenite (Na_2SeO_3) is effective in prevention of Keshan disease and treatment of Kashin-Beck disease. It has been widely used, but its safe and effective dosage, interval of drug administration and accumulation of toxicity are still unresolved. Therefore, we studied the pharmacokinetics of sodium selenite in normal humans.