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目的:观察去甲二氢愈创木酸(NDGA)对人恶性胶质瘤细胞系SHG-44细胞增殖和分化的影响。方法:细胞培养、免疫组化、光镜和电镜观察及流式细胞仪检测。结果:①在200μmol/L浓度范围内,NDGA对SHG-44细胞有增殖抑制和诱导分化作用,且这种作用与浓度呈正相关;②在NDGA处理96h内,NDGA对SHG-44细胞的增殖抑制作用以处理后24h最明显;③NDGA处理后,SHG-44细胞增殖受阻于G1→S期。结论:NDGA对SHG-44细胞有明显的增殖抑制和诱导分化作用,且这种作用有周期特异性。
Objective: To observe the effects of nordihydroguaiaretic acid (NDGA) on the proliferation and differentiation of human glioblastoma cell line SHG-44. Methods: Cell culture, immunohistochemistry, light and electron microscopy and flow cytometry. RESULTS: ① In the concentration range of 200 μmol / L, NDGA had inhibitory and differentiation-inducing effect on SHG-44 cells, and this effect was positively correlated with the concentration. (2) NDGA inhibited the proliferation of SHG-44 cells 24h after treatment was the most obvious; ③NDGA treatment, SHG-44 cell proliferation blocked in the G1 → S period. CONCLUSION: NDGA can significantly inhibit SHG-44 cells proliferation and induce differentiation, and this effect has cycle specificity.