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目的··:观察川芎嗪对吗啡依赖大鼠戒断综合征的影响。方法··:采用剂量递增方式皮下注射吗啡5d的大鼠,经过川芎嗪处理30min后,用纳洛酮催促,在停用吗啡后不同时间里观察评定戒断症状分值。结果··:川芎嗪明显减轻戒断症状和体重下降。结论··:川芎嗪能明显抑制吗啡依赖大鼠的戒断反应,其作用机制可能与阻断细胞钙内流有关。
Objective: To observe the effect of ligustrazine on withdrawal syndrome in morphine dependent rats. Methods · · ·: Rats were injected subcutaneously with morphine for 5 days in dose escalation mode. After treatment with ligustrazine for 30 minutes, naloxone was used to induce morphine withdrawal. The morphine withdrawal symptoms were evaluated at different times after morphine withdrawal. Results: Ligustrazine significantly reduced withdrawal symptoms and weight loss. Conclusion: Ligustrazine can significantly inhibit the withdrawal response of morphine-dependent rats, and its mechanism may be related to the inhibition of intracellular calcium influx.