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作者报告14年来在日本随访观察的原先诊断为慢性肝炎或肝硬变,以后经肝脏活检或尸检确诊为肝细胞癌的31例患者。年龄42～78岁,平均57.3岁。男性27例,女性4例。其中27例曾作乙型肝炎的血清学检查。HBsAg10例阳性,9例阴性,但抗HBs及/或抗HBc阳性。4例HBsAg、抗HBs和抗HBc均阴性。4例HBsAg阴性,但其他资料不全。 31例中的25例初诊为肝硬变,6例诊断为慢性肝炎,但在发现肝细胞癌前其中5例的诊断也已改为肝硬变。在发现肝细胞癌前已追踪观察了8个月至14年,平均58.9个月。HBsAg阳性组平均是48.4±7.0
The authors report 31 patients previously diagnosed with chronic hepatitis or cirrhosis at follow-up in Japan in the past 14 years and subsequently diagnosed with hepatocellular carcinoma by liver biopsy or autopsy. Aged 42 to 78 years old, with an average of 57.3 years old. 27 males and 4 females. Of these, 27 had serological tests for hepatitis B. 10 cases of HBsAg positive, 9 negative, but anti-HBs and / or anti-HBc positive. Four cases of HBsAg, anti-HBs and anti-HBc were negative. 4 cases of HBsAg-negative, but other information is not complete. Twenty-five of the 31 patients were newly diagnosed with cirrhosis and 6 were diagnosed with chronic hepatitis, but the diagnosis of 5 of them was changed to cirrhosis even before the discovery of hepatocellular carcinoma. Hepatocellular carcinoma has been followed for 8 months to 14 years, an average of 58.9 months. The average HBsAg-positive group was 48.4 ± 7.0