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目的探讨非小细胞肺癌(NSCLC)伴脑转移全脑放疗的时机及预后影响因素。方法搜集147例NSCLC伴脑转移并行全脑放疗患者的临床资料,结合随访资料进行单因素和多因素Cox比例风险模型回归分析。结果颅外转移为NSCLC脑转移患者预后的独立影响因素,比值比(OR)为1.924,95%可信区间(CI)为1.356-2.728。颅外转移、确诊脑转移到全脑放疗的时间是有脑转移症状NSCLC患者预后的独立影响因素,OR分别为1.691和2.964,95%CI分别为1.003～2.850和1.674-5.248。颅外转移是无脑转移症状NSCLC患者预后的独立影响因素,OR为1.793,95%CI为1.099-2.925。结论颅外转移是影响NSCLC伴脑转移患者预后的重要因素,及早行全脑放疗有助于提高有脑转移症状的NSCLC脑转移患者的生存期。
Objective To investigate the timing and prognostic factors of non-small cell lung cancer (NSCLC) with brain metastases. Methods The clinical data of 147 patients with NSCLC complicated with brain metastases and global brain radiotherapy were collected. The follow-up data were used to analyze the single-factor and multi-factor Cox proportional hazards models. Results Extracranial extracranial metastases were independent prognostic factors for NSCLC patients with brain metastases. The odds ratio (OR) was 1.924, 95% confidence interval (CI) was 1.356-2.728. The extracranial metastases and the time of brain metastases to whole brain radiation were the independent prognostic factors of NSCLC patients with brain metastases, OR were 1.691 and 2.964, 95% CI was 1.003-2.850 and 1.674-5.248 respectively. Extracranial metastasis was an independent prognostic factor in non-brain metastatic NSCLC patients with OR of 1.793 and 95% CI of 1.099-2.925. Conclusion Extracranial metastasis is an important factor affecting the prognosis of NSCLC patients with brain metastases. Early whole-brain radiotherapy can improve the survival of NSCLC patients with brain metastases.