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目的:评价克拉霉素对反复喘息急性加重期患儿鼻咽灌洗液中TNF-α、IL-1β和IL-10的影响。方法:将54例反复喘息急性加重期患儿为研究对象,分别给予克拉霉素与安慰剂治疗,并于治疗过程中检测患儿鼻咽灌抽吸物中TNF-α、IL-1β和IL-10含量的变化情况。结果:与安慰剂相比,克拉霉素治疗3～5天后鼻咽抽吸物中TNF-α和IL-1β显著降低(P<0.05);治疗3～8周后TNF-α、IL-1β和IL-10水平均有不同程度降低,但肺炎嗜衣原体和肺炎支原体感染患儿IL-10水平无明显影响。结论:克拉霉素能降低喘息急性加重期患儿粘膜中TNF-α、IL-1β和IL-10的浓度。
Objective: To evaluate the effect of clarithromycin on TNF-α, IL-1β and IL-10 in nasopharyngeal lavage fluid of children with recurrent wheezing acute exacerbation. Methods: Fifty-four children with recurrent wheezing and acute exacerbation were enrolled in this study. The patients were treated with clarithromycin and placebo respectively. TNF-α, IL-1β, IL -10 content changes. RESULTS: Compared with placebo, nasopharyngeal aspirates had significantly lower levels of TNF-α and IL-1β after clarithromycin treatment for 3 to 5 days (P <0.05). After 3 to 8 weeks of treatment, TNF-α and IL-1β And IL-10 levels were reduced to varying degrees, but no significant effect of IL-10 levels in children with Chlamydia pneumoniae and Mycoplasma pneumoniae infection. Conclusion: Clarithromycin can reduce the concentration of TNF-α, IL-1β and IL-10 in mucosa of children with asthma exacerbation.