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目的 分析2型糖尿病(T2DM)合并甲状腺结节(TN)男性患者的临床特征.方法 男性T2DM患者111例中,41例合并TN(TN组),70例不合并TN(non-TN组),比较两组年龄、BMI、糖脂代谢指标、性激素水平和甲状腺功能等指标差异.结果 TN组年龄[(56.70±10.79)岁vs.(50.15±11.74)岁]、BMI[(25.70±3.16)kg/m2 vs.(24.39±2.49)kg/m2]、HbA1c[(9.93±2.49)％vs.(8.97±2.13)％]、HOMA-IR(3.48±1.47 vs.2.62±2.17)、TG[(2.58±2.25)mmol/L vs.(1.76±1.29)mmol/L]和FT4水平[(36.79±31.22)pmol/L vs.(28.89±15.92)pmol/L]均高于non-TN组(P＜0.05或P＜0.01);脱氢表雄酮(DHEA)低于non-TN组[(4.54±2.28)μmol/L vs.(5.97±2.93)μmol/L](P＜0.05).结论 胰岛素抵抗在男性T2DM合并TN患者中更为严重,糖脂代谢更加紊乱,DHEA水平更低.“,”Objective To analyze clinical characteristics of male patients with type 2 diabetes mellitus (T2 DM) complicated with thyroid nodule (TN).Methods A total of 111 male patients with T2 DM was divided into two groups of TN (41 cases) and non-TN (70 cases).The differences of age, BMI, glucolipid metabolisms and the level of sex hormones and thyroid function were compared between two groups.Results Compared with group non-TN, the age [ (56.70±10.79) years old vs. (50.15±11.74) years old], BMI [ (25.70±3.16) kg/m2 vs. (24.39±2.49) kg/m2], HbA1 c [ (9.93±2.49) ％ vs. (8.97±2.13) ％], insulin resistance index (3.48±1.47 vs.2.62±2.17), TG [ (2.58±2.25) mmol/L vs. (1.76±1.29) mmol/L] and FT4 level [ (36.79±31.22) pmol/L vs. (28.89±15.92) pmol/L] were all higher in group NT (P＜0.05 or P＜0.01), but dehydroepiandrosterone (DHEA) was lower in group NT [ (4.54±2.28) μmol/L vs. (5.97±2.93) μmol/L] (P＜0.05).Conclusion Male T2 DM patients complicated with TN are more prone to have disturbances in insulin resistance and glucolipid metabolisms as well as lower level of DHEA.