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２５只白兔用卵清蛋白为抗原经全身和鼻粘膜局部免疫，４ｗ后其中１７只动物血清卵清蛋白特异性ＩｇＥ抗体上升到免疫前的５倍以上，并经抗原刺激鼻粘膜诱发出打喷嚏样反应、流清涕等变应性鼻炎样临床症状。这１７只动物用作Ⅰ型变态反应动物模型，其中９只进一步用制备的异种基因型ＩｇＥＦｃε片段为抗原免疫。２ｗ后在血清中检测到较高浓度的抗ＩｇＥ抗体，同时伴有血清总ＩｇＥ抗体浓度下降，上述变化持续观察１０ｗ无明显改变。提示异常增高的ＩｇＥ抗体水平可通过诱导机体产生内源性抗ＩｇＥ抗体的方式抑制。
25 rabbits with ovalbumin as antigen by local and nasal mucosa local immunization, after 4w, 17 of them serum ovalbumin-specific IgE antibody rose to 5 times before immunization, and antigen-induced nasal mucosa induced by the fight Sneeze-like reaction, runny nose and other allergic rhinitis-like clinical symptoms. The 17 animals were used as type I allergic animal models, of which 9 were further immunized with the prepared xenotypic IgEFc [epsilon] fragment for the antigen. After 2 weeks, a higher concentration of anti-IgE antibody was detected in the serum, accompanied by a decrease in serum total IgE antibody concentration. The above changes were observed for 10 weeks without any significant change. Suggesting that abnormally elevated IgE antibody levels can be inhibited by inducing the body to produce endogenous anti-IgE antibodies.