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结肠灌注液Ⅰ号对氯化汞、甘油及藏红花红 O 所致小鼠、大鼠及家兔之中毒性及缺血性 ARF 均有显著防治效果,能使 ARF 动物血清尿素氮、肌酐明显下降,尿量增加,尿内尿素氮及钾排量增加,并能明显延迟 ARF 动物的死亡时间,降低死亡率。该液之抗ARF 效果与其能增加肾血流量,改善肾微循环,从而改善肾的供血供氧;减轻肾间质水肿,减轻肾小管坏死程度及管腔内管型,从而减少肾小管内阻塞,减轻肾小球滤过液返流;促进水份从肠道排出,促进纤维蛋白溶解和纤维蛋白(原)降解,促进坏死之肾小管再生修复等有关。
The colon perfusion solution No.I had significant effects on the toxic and ischemic ARF in mice, rats and rabbits caused by mercury chloride, glycerol and saffron red O, which could significantly reduce serum urea nitrogen and creatinine in ARF animals. Increased urine output, increased urea nitrogen and potassium in the urine, and can significantly delay the death time of ARF animals and reduce mortality. The anti-ARF effect of the liquid can increase the renal blood flow, improve renal microcirculation, thereby improving renal blood supply and oxygen supply; reduce renal interstitial edema, reduce tubular necrosis and intraluminal tube type, thereby reducing tubular obstruction , Reducing glomerular filtration fluid reflux; promoting water excretion from the intestine, promote fibrinolysis and fibrin (raw) degradation, promote necrosis of renal tubular regeneration and other related.