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目的探讨支气管哮喘患者血清白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、白细胞介素-16(IL-16)和免疫球蛋白IgE的动态变化和检测的临床意义。方法收集30例支气管哮喘发作期患者(哮喘组)和30例正常对照者(对照组)的血清,采用酶联免疫吸附试验(ELISA)测定血清中IL-6、IL-10、IL-16和总IgE。结果与正常对照组比较,哮喘组血清IL-6、IL-16和总IgE水平明显增高,相比较有显著性差异(P<0.05);而IL-10水平明显降低,相比较有显著性差异(P<0.05);哮喘组总IgE与IL-6、IL-16之间呈正相关(r=0.6871,r=0.8633,P<0.01);与IL-10之间存在负相关(r=-0.4782,P<0.01)。结论IL-6、IL-10、IL-16和总IgE与哮喘发病机制有关,动态测定这些指标有助于病情评估。
Objective To investigate the dynamic changes and detection of serum interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-16 (IL-16) and IgE in patients with bronchial asthma significance. Methods Thirty patients with bronchial asthma exacerbation (asthma group) and 30 normal control (control group) sera were collected. Serum levels of IL-6, IL-10 and IL-16 were measured by enzyme linked immunosorbent assay Total IgE. Results Compared with the normal control group, the levels of serum IL-6, IL-16 and total IgE in the asthma group were significantly higher than those in the normal control group (P <0.05), while the levels of IL-10 were significantly decreased (P <0.05). There was a positive correlation between total IgE and IL-6 and IL-16 in asthma group (r = 0.6871, r = 0.8633, , P <0.01). Conclusion IL-6, IL-10, IL-16 and total IgE are related to the pathogenesis of asthma. The dynamic measurement of these indexes is helpful to evaluate the condition.