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目的:利用超声造影研究高分化和低分化肝癌患者的肿瘤血流灌注情况,探讨超声造影在肝癌分级的诊断价值。方法:选择我院原发性肝癌(HCC)患者65例并根据活检肝细胞癌病变和肿瘤分级不同分为A组37例(高分化组)和B组28例(低分化组),对两组患者行超声造影检查,分析超声造影的血流灌注状态。结果:A组与B组病灶的到达时间(AT)、峰值时间(TTP)和峰值强度(PI)均存在显著的差异性(tAT=7.266,PAT=0.000;t TTP=5.966,P TTP=0.000;tPI=8.219,PPI=0.000)。A组与B组间的病灶增强时间(1)、增强斜率(2)、清除时间(3)、清除斜率(4)具有差异,并且差异具有统计学意义(t1=7.266,P1=0.000;t2=8.317,P2=0.000;t3=8.880,P3=0.000;t4=6.178,P4=0.000)。结论:超声造影可作为一种新型的肝癌分级方法,对于早期诊断肝癌和获得肿瘤分级具有很大的临床价值。
OBJECTIVE: To study the tumor perfusion in patients with well-differentiated and poorly-differentiated hepatocellular carcinoma by contrast-enhanced ultrasound and to evaluate the diagnostic value of contrast-enhanced ultrasound in the classification of liver cancer. Methods: A total of 65 patients with primary hepatocellular carcinoma (HCC) were selected and divided into three groups according to their biopsy grade and tumor grade: 37 cases in group A (well-differentiated group) and 28 cases in group B (poorly differentiated group) Group patients underwent contrast-enhanced ultrasound, angiography of the perfusion state. Results: The time of arrival (AT), peak time (TTP) and peak intensity (PI) of group A and group B were significantly different (tAT = 7.266, PAT = 0.000; t TTP = 5.966, P TTP = 0.000 ; tPI = 8.219, PPI = 0.000). The time of lesion enhancement (1), enhancement slope (2), clearance time (3) and clearance slope (4) between group A and group B were different and the difference was statistically significant (t1 = 7.266, P1 = 0.000; = 8.317, P2 = 0.000; t3 = 8.880, P3 = 0.000; t4 = 6.178, P4 = 0.000). Conclusion: Contrast-enhanced ultrasound can be used as a new classification method for liver cancer, which has great clinical value for early diagnosis of liver cancer and tumor grade.