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目的:观察绞股蓝颗粒对糖尿病肾病模型大鼠血管活性物质表达的影响,探讨其治疗糖尿病肾病的作用机制。方法:利用单侧肾切除加STZ注射法改良复制糖尿病肾病大鼠模型,分为正常组、模型组、治疗组(绞股蓝颗粒高、中、低剂量组及缬沙坦对照组),观察糖尿病肾病模型大鼠肾组织ET-1、NO含量、ETRmRNA的表达的变化。结果:治疗组肾组织ET-1及NO含量显著减少,肾组织ETARmRNA明显下调,与模型对照组相比,差异有显著统计学意义(P<0.05或P<0.01)。结论:绞股蓝颗粒可用于治疗早期糖尿病肾病,其机制可能与其调节血管活性物质紊乱有关。
OBJECTIVE: To observe the effect of Gynostemma Granules on the expression of vasoactive substances in diabetic nephropathy model rats and to explore its mechanism of action in the treatment of diabetic nephropathy. METHODS: Unilateral nephrectomy plus STZ injection was used to improve the rat model of diabetic nephropathy. The rats were divided into normal group, model group, and treatment group (high-, middle-, and low-dose groups of gynostembra granules and valsartan control group) to observe diabetic nephropathy. Changes of ET-1, NO, and ETR mRNA expression in renal tissue of model rats. Results: In the treatment group, the content of ET-1 and NO in kidney tissue was significantly decreased, and the ETAR mRNA in kidney tissue was significantly down-regulated. Compared with the model control group, the difference was statistically significant (P<0.05 or P<0.01). CONCLUSION: Gynostemma granules can be used for the treatment of early diabetic nephropathy, and its mechanism may be related to its regulation of vasoactive substance disorders.