作者用VAD方案治疗多发性骨髓瘤33例,其它恶性淋巴疾患16例以及VAD方案治疗后复发者再给VAD方案治疗3例,共52例可供毒性分析。方法:长春新碱1.6mg+阿霉素36mg/m~2混合静脉滴注,每日1次,连续4天,并口服地塞米松每日40mg,连续4天,隔21天重复。多发性骨髓瘤平均治疗5个疗程,其它恶性淋巴疾患平均给药4个疗程。毒性:恶心10%,体重增加和减轻各占33%,消化不良33%,充血性心力衰竭6%,败血症23%,肺部感染19%。9例死于感染。疗效:33例多发性骨髓瘤有20例达部分缓 The authors treated 33 patients with multiple myeloma with VAD regimen, 16 with other malignant lymphomas and 3 with VAD regimen after VAD regimen. A total of 52 were available for toxicity analysis. Methods: vincristine 1.6mg + doxorubicin 36mg / m ~ 2 mixed intravenous infusion, once daily for 4 days, and daily oral dexamethasone 40mg, for 4 days, repeated 21 days. The average treatment of multiple myeloma 5 courses of treatment, other malignant lymphatic disease averaged 4 courses. Toxicity: nausea 10%, weight gain and relief 33%, indigestion 33%, congestive heart failure 6%, sepsis 23%, lung infection 19%. Nine patients died of infection. Efficacy: 20 cases of 33 cases of multiple myeloma up to some slow