热能限制(caloric restriction,CR)被称为衰老研究领域最重大的发现,即在满足机体对各种营养素需要量的前提下,适当限制食物摄入,又称饮食限制(dietary restriction,DR)。McCay等于1935年首次报道CR延长大鼠寿限,迄今70余年来,大量实验研究证实,CR能明显延缓衰老,延长实验动物的寿命,推迟和降低老年相关疾病的发生。由于世界范围内人口老龄化 Caloric restriction (CR) is called the most significant discovery in the field of aging research. That is to say, dietary restriction (DR) is appropriately restricted when it meets the body’s requirements for various nutrients. For the first time in 1935, McCay reported that CR prolongs the lifespan of rats. So far, more than 70 years of research have shown that CR can significantly delay aging, prolong the lifespan of experimental animals, delay and reduce the incidence of age-related diseases. Due to the aging of the world population