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目的探讨糖化血红蛋白和N末端脑钠肽原与急性冠状动脉(冠脉)综合征心功能的相关性。方法 68例急性冠脉综合征患者,根据有无合并糖尿病分为A组(34例,合并糖尿病)、B组(34例,无糖尿病),并以同期到本院体检的34例健康者作为C组。对比分析三组血清中糖化血红蛋白、N末端脑钠肽原的水平。结果 A组血清中糖化血红蛋白水平明显高于B、C组(P<0.05),但B、C组间比较差异无统计学意义(P>0.05);A、B组血清中N末端脑钠肽原水平明显高于C组(P<0.05),且A组高于B组(P<0.05);糖化血红蛋白和N末端脑钠肽原表达水平随着急性冠脉综合征心功能病情加重而提升,呈正相关(P<0.05)。结论急性冠脉综合征患者血清中糖化血红蛋白和N末端脑钠肽原水平明显提升,联合检测能对心功能进行评估。
Objective To investigate the relationship between glycated hemoglobin and N-terminal pro-brain natriuretic peptide and the cardiac function of acute coronary syndrome (coronary syndrome). Methods Sixty-eight patients with acute coronary syndrome (ACS) were divided into group A (34 patients with diabetes mellitus) and group B (34 patients without diabetes mellitus) according to the presence or absence of diabetes mellitus. 34 healthy subjects Group C The levels of glycated hemoglobin and N-terminal pro-brain natriuretic peptide were compared among the three groups. Results The level of serum HbA1c in group A was significantly higher than that in group B and C (P <0.05), but there was no significant difference between group B and C (P> 0.05) The levels of HbA1c and N-terminal pro-brain natriuretic peptide increased with the severity of acute coronary syndrome (ACS). The levels of HbA1c and N-terminal pro-brain natriuretic peptide were significantly higher than those in group C (P <0.05) , There was a positive correlation (P <0.05). Conclusions The serum levels of HbA1c and N-terminal pro-brain natriuretic peptide in patients with acute coronary syndrome are significantly increased. The combined detection of cardiac function can be assessed.