目的测定猪颈总动脉狭窄前后血流动力学变化参数,为进一步研究打下基础。方法按文献建立猪颈总动脉粥样硬化狭窄模型。用彩色多普勒血流成像技术测量狭窄前后颈内动脉及大脑中动脉血流速度及血流量的变化。结果颈总动脉粥样硬化性狭窄前、后,大脑中动脉收缩期峰值血流速度(PSV)分别为(95.78±9.86)cm/s和(72.04±12.24)cm/s。颈总动脉狭窄前及狭窄后2个月颈内动脉PSV分别为(113.09±19.92)cm/s和(244.76±52.30)cm/s,血流量分别为(355.379±38.08)ml/min和(191.36±39.27)ml/min;两者比较,均相差显著(P<0.05)。结论猪颈总动脉严重狭窄后,颅内动脉灌注压明显下降及颅内血流量明显减少。 Objective To determine the parameters of hemodynamics before and after the stenosis of porcine carotid artery and lay the foundation for further study. Methods According to the literature, the common carotid artery atherosclerosis stenosis model was established. Color Doppler flow imaging was used to measure the changes of blood flow velocity and velocity in the internal carotid artery and the middle cerebral artery before and after stenosis. Results Before and after common carotid atherosclerosis, the peak systolic velocity (PSV) of the middle cerebral artery was (95.78 ± 9.86) cm / s and (72.04 ± 12.24) cm / s, respectively. The PSV of internal carotid artery were (113.09 ± 19.92) cm / s and (244.76 ± 52.30) cm / s respectively before and 2 months after carotid artery stenosis, and the blood flow were (355.379 ± 38.08) ml / min and (191.36 ± 39.27) ml / min respectively. There was a significant difference between the two groups (P <0.05). Conclusion Severe stenosis of pig carotid artery, intracranial arterial perfusion pressure decreased significantly and intracranial blood flow decreased significantly.