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目的:探讨感染性心内膜炎采用竹叶石膏汤联合足量抗生素治疗的临床效果。方法:选择鹤山市中医院2013年4月至2014年7月收治的70例感染性心内膜炎患者,随机分为2组,每组35例。对照组在常规治疗的基础上给予头孢替唑钠、炎琥宁注射液治疗,观察组在对照组的基础上给予竹叶石膏汤治疗,比较两组治疗效果、治疗前后中医症候积分、超敏C反应蛋白(hs-CRP)、血沉(ESR)、血清降钙素原(PCT)变化情况。结果:观察组治疗总有效率为94.3%,高于对照组的71.4%,差异具有统计学意义(P<0.05);治疗后观察组hs-CRP、ESR、PCT、中医症状积分均低于对照组,差异具有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:感染性心内膜炎采用竹叶石膏汤联合足量抗生素治疗效果确切,能有效改善患者临床症状及体征,降低炎症反应,安全性高、不良反应少。
Objective: To investigate the clinical efficacy of bamboo leaf gypsum soup combined with adequate antibiotics in infective endocarditis. Methods: Seventy patients with infective endocarditis admitted from April 2013 to July 2014 in Heshan Hospital of Traditional Chinese Medicine were randomly divided into two groups (n = 35 in each group). The control group was treated with ceftezole sodium and Yanhuning injection on the basis of routine treatment. The observation group was treated with bamboo leaf gypsum soup on the basis of the control group. The treatment effect was compared between the two groups before and after treatment. The symptom scores of TCM symptoms, hypersensitivity C reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), serum procalcitonin (PCT) changes. Results: The total effective rate of observation group was 94.3%, which was higher than that of control group (71.4%), the difference was statistically significant (P <0.05); after treatment, the scores of hs-CRP, ESR, Group, the difference was statistically significant (P <0.05). The incidence of adverse reactions in the two groups, the difference was not statistically significant (P> 0.05). Conclusion: Infective endocarditis with bamboo leaf gypsum soup combined with adequate antibiotics treatment effect, can effectively improve the clinical symptoms and signs, reduce the inflammatory response, high safety, fewer adverse reactions.