论文部分内容阅读
双氯芬酸是一种强效非甾体消炎药,抗炎作用高于甲芬那酸,镇痛比吲哚美辛强2～3倍,比阿司匹林强26～50倍,使用剂量是现行解热镇痛药中最少的品种之一,已列入美国非处方药(OTC).国内以针剂、片剂和复方制剂(如感冒通)为主,现也有凝胶和乳剂应市.国外有欧洲出品的 almiral gel凝胶剂和汽巴公司的 voltaren emulgel乳胶剂,这是一种由水溶性聚合物为基质的无色透明半固体,可水洗、无油腻感.为此.我们研制了一种类似的凝胶剂.并对其透皮吸收等作了实验研究.1 材料与方法1.1 凝胶剂处方组成及选择:双氯芬酸为水溶性药物,经皮渗透作用小,在一定范围内药物通过皮肤的渗透系数与油-水分配系数有平行关系.选择合适的亲水、亲脂性介质可影响药物的溶解度和皮肤
Diclofenac is a potent non-steroidal anti-inflammatory drugs, anti-inflammatory effect than mefenamic acid, analgesic stronger than indomethacin 2 to 3 times stronger than aspirin 26 to 50 times the dose is the current antipyretic town One of the least varieties of painkillers has been included in the United States OTC (OTC) .In the country with injections, tablets and compound preparations (such as flu), there are also gels and emulsions should be abroad .Almiral gel gel and Ciba’s voltaren emulgel latex, a colorless and transparent semi-solid based on a water-soluble polymer, washable and greasy, for which reason we developed a similar gel And its transdermal absorption and other experiments were made.1 Materials and methods 1.1 gel formulations prescription and choice: diclofenac water-soluble drugs, transdermal penetration is small, within a certain range of drug permeability coefficient through the skin And oil - water partition coefficient has a parallel relationship.Select the appropriate hydrophilic, lipophilic medium can affect the solubility of drugs and skin