采用免疫组化法对５０例人脑星形胶质细胞瘤组织中Ｐ５３蛋白的表达，及其与肿瘤临床病理学特征和预后的关系作了分析，结果显示：本组５０例中２２例表达阳性，阳性率占４４％，Ｐ５３蛋白主要分布在细胞核内，正常脑组织Ｐ５３蛋白表达均为阴性，且肿瘤分化程度越差，预后不良者其阳性染色愈强烈，提示Ｐ５３基因及其蛋白与人脑星形胶质细胞瘤的发生、发展密切相关，可做为判定脑肿瘤恶性程度和预后的重要指标。 The expression of P53 protein in 50 human brain astrocytomas and its relationship with clinicopathological features and prognosis were analyzed by immunohistochemistry. The results showed that 22 of the 50 cases were expressed Positive and positive rate accounted for 44%, P53 protein mainly in the nucleus, P53 protein expression in normal brain tissue were negative, and the worse the degree of tumor differentiation, poor prognosis positive stained more strongly, suggesting P53 gene and its protein Cerebral astrocytoma occurrence and development are closely related, can be used as an important indicator to determine the degree of malignancy and prognosis of brain tumors.